Sertraline although it is in the category of SSRIs is the most dopaminergic of all. So this is a good agent to prescribe for someone with a diagnosis of MDD  who have little energy, no motivation, loss of appetite. This has been referred to an anergic depression in the past. 

 I do avoid it in those with any component of anxiety as you know the dopamine can worsen symptoms of anxiety at least initially. 

Escitalopram is considered the best option and has the least amount of  CYP450 drug mediated interactions.

 Why would it be imperative to complete a MDQ prior to prescribing an SSRI?


a. Answer the following question above.  Engage by offering new insights, applications, perspectives, information, or implications for practice. Communicate using respectful, collegial language and terminology appropriate to advanced nursing practice. Communicate with minimal errors in English grammar, spelling, syntax, and punctuation. Use current 7th edition APA format to format citations and references and is free of errors. References must be within 5 years. And scholarly. A total of 2 references are needed with one reference provided for you below.

Stahl, S. M. (2021).  Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (5th ed.). Cambridge University Press.